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When starting ArcGIS Pro, the application fails and returns the following error:
Error: ArcGIS Pro has encountered a serious application error and is unable to continue.
This is a generic error message that can occur from different causes, however when starting ArcGIS Pro, this error often occurs because the user .config file is corrupted.
Create a new .config file
To locate and delete the corrupted user.config file by following the steps below:
Note: It may be necessary to enable viewing of hidden folders to view the AppData folder in Windows.