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ArcMap performs extremely slowly after saving or exporting any mxd files. The slow performance can also be triggered after working on an MXD for 1 to 30 minutes.
ArcMap performs at normal speed until the performance issue is triggered. Once it is triggered, the CPU usage may hang around 8 to 20%, even while ArcMap sits idle.
There is a spyware virus called TSPY_AGENT.DE that is planting .dil and .dat files in the system32 folder.
The solution below may not remove the entire virus, but should restore performance in ArcMap.
Additional solutions can be found on the Trend Micro Web site listed below.