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A conflict occurs when McAfee Virus Scan operates on a machine using Threatfire Virus Scan.
When these anti-virus applications run simultaneously, most of the ArcGIS 9.3 Geoprocessing tools in ArcToolbox, as well as many exporting functions, generate a generic 99999 error and do not function.
PC Tools Threatfire 220.127.116.11 and later versions are causing a conflict when it is run simultaneously with McAfee Virus Scan.
Disabling the virus scanning capabilities of the Threat Fire application allows the tools in the ArcToolbox to work properly, after restarting ArcGIS 9.3.