ArcMap runs very slow on client machines accessing ArcGIS by way of Citrix 4.5 ICA connection

Description

When opening a map document or performing selection tasks in ArcMap that are accessed by way of a Citrix 4.5 ICA connection, there is a noticeable performance slowdown with ArcGIS Desktop products.

Cause

The Citrix 4.5 Hotfix Rollup Pack 6 re-introduced a previously resolved performance fix.

Solution or Workaround