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Using ArcMap print preview is slow if the map page size is large, if the map uses transparent symbology, and/or has raster layers.
The purpose of print preview is to check the page size and layout of the map on the printer page. It is not intended to view how the map elements look on the map page; do that in ArcMap Layout view.
Turn off all layers in a single data frame by pressing and holding the control key and clicking the one layer check box.