PROBLEM
ArcGIS Pro is unable to connect to a Microsoft SQL Server enterprise geodatabase and returns an error when creating a database connection or running geoprocessing tools that require access to the enterprise geodatabase:
"DBMS unable to connect"
This issue may occur even when SQL Server services are running, network connectivity is available, required protocols are enabled, and database credentials are valid.
The SQL Server port specified in the ArcGIS Pro database connection properties is incorrect, as shown in the next image:

Although SQL Server may be reachable through SQL Server Management Studio (SSMS) and other network connectivity tests may succeed, ArcGIS Pro requires the correct SQL Server port to establish the database connection. If an incorrect port is specified, ArcGIS Pro returns the "DBMS unable to connect" error and enterprise geodatabase tools fail to connect.
Use the following troubleshooting workflow to isolate the source of the connection failure:

In this case, the issue was resolved after specifying the correct SQL Server port (1443) in the ArcGIS Pro database connection properties, as shown in the image above. Once the port was corrected, ArcGIS Pro successfully connected to the SQL Server database and enterprise geodatabase operations completed successfully.
Article ID: 000042406
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