Editing with a Topology that is empty and does not contain any feature classes results in ArcMap failing with the following error message:
"Could not edit the data in the folder or database you selected.
The operation is not supported on an uninitialized object. [DirtyAreaManager]"
Additionally, the error message may be appended with:
"The table was not found.
The Microsoft Jet database engine cannot find the input table or query 'GDB_ReplicaChanges'. Make sure it exists and that its name is spelled correctly."
There is a Topology layer that is empty and does not contain any feature classes.