In ArcGIS Pro, when the 'Enable and disable editing from the Edit tab' setting is enabled, the Save button is grayed out after using the Calculate Geometry tool from the attribute table.

Workaround

After completing the geometry calculation, a change needs to be made and erased (such as adding a blank row in the attribute table and deleting it) so the Save button can register a change and become clickable. Then, clicking the Save button saves the geometry calculation made.

Steps to Reproduce