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In ArcGIS Pro, the domains view is accessible from the Data tab or from the Fields and Subtypes tabs. This allows users to view existing domains, edit their properties and values, and create new domains. In some instances, when attempting to set domains to a set of data in ArcGIS Pro, the Domains button is disabled.
The Domains button is only active if the data type is a file geodatabase feature class. Data types, such as shapefiles and dBASE (.dbf) tables, do not support some of the capabilities found in geodatabases, such as domains and subtypes.
On another note, there is a known issue in ArcGIS Pro 1.1 and 1.2 where the changes made to domains, subtypes, and indexes using geoprocessing tools may not be reflected in the Design Views. For more information on issues addressed at ArcGIS Pro 1.1 and 1.2, refer to the following ArcGIS Web Help pages, Release Notes for ArcGIS Pro 1.1 and Release Notes for ArcGIS Pro 1.2.
To enable the Domains button, ensure the data is saved as a file geodatabase feature class. If the data comes from an older version of ArcGIS Desktop (such as ArcGIS Desktop 10.0), use the Create File Geodatabase tool to create a file geodatabase that corresponds to an older release of ArcGIS Desktop that can be used in ArcGIS Pro. For more information on how to create a file geodatabase to work with ArcGIS Pro, refer to the following ArcGIS Web Help page: Create a file geodatabase.
If this problem still occurs in ArcGIS Pro 1.1 or 1.2, close and reopen the project.