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Error: Unable to save. Check to make sure you have write access to the specified file...

Error Message

Saving a Map Document returns the error:

"Unable to save. Check to make sure you have write access to the specified file and that there is enough space on the storage device to hold your document."

Cause

One possible reason for this error message is that another user has opened the map document before the current user. If this is not the case, contact ESRI Technical Support.

When User A opens an MXD in Windows, they recieve read/write privileges. When User B opens the same MXD while User A has it open, they get read privileges. User A can make changes and save, User B cannot and never will be able to, even if User A closes ArcMap.

Solution or Workaround

User B in the above scenario should close the map document, and check for others editing the same MXD, or try reading/writting the MXD once again.

Note:
Alternatively, the file can be saved by using 'Save As' and either renaming the file and saving it to the same directory or saving a file of the same name in another directory.

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