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When saving an MXD to a network drive location, either of two errors occur:
"Windows delayed write failed!
Windows was unable to save all of the data for the file <name>.
The data has been lost.
This error may be caused by a failure of your computer or your network connection.
Please try to save your file elsewhere."
"Unable to save. Check to make sure you have write access to the specified file and that there is enough space on the storage device to hold your document".
This is a known Microsoft issue.
The workaround provided by Microsoft is as follows. Please note that this is a Microsoft issue and not one that Esri can fix.